PhD Student position in Cellular and Molecular Biology - Nextimmune DTU - JS0218- LCSB

NEXTIMMUNE, standing for “Next Generation ImmunoScience: Advanced Concepts for Deciphering Acute and Chronic Inflammation”, is a competitive PhD training program, supported by the doctoral research funding scheme PRIDE of the Luxembourg National Research Fund FNR. It aims to bridge classical immunology and big-data analysis science in a structured doctoral training environment.
29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
29/01/2019 14:19:32

With up to 4 years fixed-term contract, full-time. Start date flexible from now on until July 2019. Supervisor: Prof. Dr. Jochen Schneider, Translational and Experimental Medicine (TEM) group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.

Project : Role of IRG-1 in inflammatory vascular diseases

Research keywords: Immune response gene 1, itaconic acid, Atherosclerosis, metabolism, inflammation

Cutting edge: defining a novel player as potential target mechanism for inflammatory vascular diseases

Collaborations: Dr. Johannes Meiser (LIH), Dr. Alessandro Michelucci (LIH), Dr . Alex Skupin (LCSB)

Inflammatory vascular disease such as atherosclerosis or  vascular inflammation affect a large number of subjects of the world population. Since vascular diseases represents a lipid-driven inflammation the pathophysiology requires a wiring of metabolism and immune system.  IRG1 is a macrophage specific gene characteristic for immune system activation and is induced by bacterial stimuli as well as oxLDL. The IRG-1 dependent production of the substrate itaconic acid (ITA) directly interferes with cellular tricarboxylic cycle (TCA) metabolism. IRG-1 also mediates the production of reactive oxygen species (ROS) in macrophages. These data suggest that IRG-1 links innate immune activation with metabolism. We aim to characterize the role if IRG-1 in inflammatory vascular disease in vivo and in vitro. This project aims at defining a novel player as potential target mechanism for inflammatory processes in the vasculature.

Requirements of the ideal candidate:

·         Master degree in biology,  life sciences or a related discipline.

·         Strong wet laboratory and analytical skills.

·         Prior experience in molecular biology tools is desired.

·         Experience with cell culture techniques and animal handling is required.

·         Excellent working knowledge of English.


We offer:

·         Opportunity to do applied research of clinical relevance within a highly dynamic research institution (LCSB) and in collaboration with internationally recognized partners.

·         An exciting international environment.

·         A very competitive salary

         Applications including a motivation letter describing past research experience and future interests, at least two confidential references letters, a full curriculum vitae and a copy of the relevant diplomas showing marks should be sent via the Apply button ONLY  - Ref: VD/PHDNI0218/MO/LCSB-DII before 30 June 2019. Only complete applications will be considered



More specific information on NEXTIMMUNE can be obtained from the program coordinator, Prof Markus Ollert, Director of LIH’s Department of Infection and Immunity: For more information on the Research Project, please contact Prof. Dr. Jochen Schneider :